HitPredict

Interactor 1: HNRPK (P61978)
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)
Gene: HNRNPK

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	25416956, 31980649, 20936779, 19380743, 21988832, unassigned2173, 12577067
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0007165 - signal transduction and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 463 Hs			1 217
+	Mm
		904258 HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Rn
		904380 HNRPK_RAT (1-463): 1.31e-129: 385: 100.00		GRB2_RAT (1-217): 6.71e-76: 229: 100.00
+	Hs
		782763 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		904174 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67
+	Hs
		548674 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Mm
		654976 HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00		VAV_MOUSE (2-60): 8.53e-15: 74.6: 42.37
+	Hs
		412116 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		442807 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		903956 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Hs
		433678 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Mm
		639439 HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47
+	Hs
		522880 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		275183 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Hs
		924755 FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924788 FUBP3_HUMAN (331-457): 1.39e-11: 68.5: 24.41		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		434107 IF2B2_HUMAN (267-463): 6.52e-12: 69.7: 15.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522876 PCBP3_HUMAN (2-114): 1.36e-12: 70.9: 16.24		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		522998 PCBP2_HUMAN (23-131): 1.39e-12: 70.9: 23.21		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		433946 FUBP3_HUMAN (331-457): 1.39e-11: 68.5: 24.41		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		789115 PCBP1_HUMAN (23-127): 3.42e-12: 69.7: 23.15		FRK_HUMAN (150-212): 6.98e-11: 62.7: 27.78