HitPredict

Interactor 1: HNRPK (P61979)
Heterogeneous nuclear ribonucleoprotein K (hnRNP K)
Gene: Hnrnpk

Interactor 2: SRSF7 (Q8BL97)
Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	26336360, 34133714
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003729 - mRNA binding GO:0005737 - cytoplasm GO:0019904 - protein domain specific binding GO:0048025 - negative regulation of mRNA splicing, via spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 463 Mm			1 267
+	Hs
		903884 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		SRSF3_HUMAN (39-125): 5.1e-29: 109: 70.12
+	Mm
		904238 HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00		SRSF3_MOUSE (39-125): 5.1e-29: 109: 70.12
+	Mm
		904278 HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00		SRSF1_MOUSE (35-229): 1.31e-20: 89.6: 27.59
+	Hs
		516439 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		PABP1_HUMAN (31-235): 1.09e-18: 87.2: 16.19
+	Mm
		665747 HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00		PABP1_MOUSE (31-235): 1.29e-18: 87.2: 16.19
+	Mm
		904294 HNRPK_MOUSE (1-463): 1.31e-129: 385: 100.00		RBM4_MOUSE (41-118): 1.26e-12: 68.8: 33.33
+	Hs
		904110 HNRPK_HUMAN (1-463): 1.31e-129: 385: 100.00		RBM4_HUMAN (41-118): 1.87e-12: 68.4: 33.33
+	Dm
		2536 NOVA_DROME (40-224): 1.12e-32: 133: 25.13		Q9VYD8_DROME (37-110): 6.74e-27: 103: 72.97
+	Dm
		2420 NOVA_DROME (40-224): 1.12e-32: 133: 25.13		RX21_DROME (35-229): 3.82e-22: 92.6: 37.76
+	Mm
		888818 PCBP1_MOUSE (23-127): 3.42e-12: 69.7: 23.15		SRSF7_MOUSE (1-267): 1.42e-32: 121: 100.00
+	Hs
		884293 PCBP3_HUMAN (2-114): 1.36e-12: 70.9: 16.24		SRSF3_HUMAN (39-125): 5.1e-29: 109: 70.12
+	Hs
		951975 PCBP2_HUMAN (23-131): 1.39e-12: 70.9: 23.21		SRSF3_HUMAN (39-125): 5.1e-29: 109: 70.12
+	Mm
		888801 PCBP1_MOUSE (23-127): 3.42e-12: 69.7: 23.15		SRSF3_MOUSE (39-125): 5.1e-29: 109: 70.12
+	Hs
		952198 IF2B2_HUMAN (267-463): 6.52e-12: 69.7: 15.00		SRSF3_HUMAN (39-125): 5.1e-29: 109: 70.12
+	Hs
		1031509 IF2B2_HUMAN (267-463): 6.52e-12: 69.7: 15.00		PABP4_HUMAN (31-124): 1.16e-19: 90.2: 26.26
+	Hs
		516531 PCBP2_HUMAN (23-131): 1.39e-12: 70.9: 23.21		PABP1_HUMAN (31-235): 1.09e-18: 87.2: 16.19
+	Hs
		516769 IF2B2_HUMAN (267-463): 6.52e-12: 69.7: 15.00		PABP1_HUMAN (31-235): 1.09e-18: 87.2: 16.19
+	Hs
		963557 FUBP2_HUMAN (200-463): 3.03e-12: 70.9: 14.29		TIAR_HUMAN (36-119): 1.3e-14: 74.4: 26.44
+	Mm
		857294 PCBP1_MOUSE (23-127): 3.42e-12: 69.7: 23.15		TIA1_MOUSE (35-198): 7.62e-15: 75.2: 15.25
+	Hs
		963587 IF2B2_HUMAN (267-463): 6.52e-12: 69.7: 15.00		TIAR_HUMAN (36-119): 1.3e-14: 74.4: 26.44