HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: UBP46 (P62068)
Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46)
Gene: USP46

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 366
+	Hs
		905373 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		UBP46_HUMAN (1-366): 1.46e-142: 410: 100.00
+	Hs
		905377 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		UBP46_HUMAN (1-366): 1.46e-142: 410: 100.00
+	Hs
		259272 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		UBP12_HUMAN (1-366): 6.21e-137: 396: 88.53
+	Hs
		259277 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		UBP12_HUMAN (1-366): 6.21e-137: 396: 88.53
+	Hs
		683244 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		UBP46_HUMAN (1-366): 1.46e-142: 410: 100.00
+	Hs
		777027 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		UBP8_HUMAN (4-363): 5.23e-103: 329: 26.37
+	Hs
		905375 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		UBP46_HUMAN (1-366): 1.46e-142: 410: 100.00
+	Mm
		910281 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		UBP8_MOUSE (1-363): 3.06e-102: 326: 26.17
+	Hs
		777025 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		UBP8_HUMAN (4-363): 5.23e-103: 329: 26.37
+	Hs
		259266 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		UBP12_HUMAN (1-366): 6.21e-137: 396: 88.53
+	Hs
		777034 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		UBP8_HUMAN (4-363): 5.23e-103: 329: 26.37
+	Hs
		910137 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		UBP21_HUMAN (19-366): 6.83e-100: 308: 24.67
+	Hs
		905236 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		UBP21_HUMAN (19-366): 6.83e-100: 308: 24.67
+	Hs
		905265 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		UBP22_HUMAN (28-365): 9.67e-99: 304: 25.92
+	Hs
		982605 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		UBP21_HUMAN (19-366): 6.83e-100: 308: 24.67
+	Hs
		982625 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		UBP22_HUMAN (28-365): 9.67e-99: 304: 25.92
+	Hs
		927542 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		UBP42_HUMAN (35-364): 3.66e-105: 338: 26.51
+	Hs
		683179 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		UBP8_HUMAN (4-363): 5.23e-103: 329: 26.37
+	Hs
		777029 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		UBP8_HUMAN (4-363): 5.23e-103: 329: 26.37
+	Zm
		22585 B6U284_MAIZE (2-247): 2.84e-141: 397: 59.68		A0A1D6I2F1_MAIZE (36-349): 9.98e-37: 143: 30.34