HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: CDK16 (Q00536)
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
Gene: CDK16

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	32707033, 12154078, 35271311, 36931259, 17353931
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 496
+	Hs
		909448 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CDK16_HUMAN (1-496): 2.61e-178: 511: 100.00
+	Hs
		960357 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		CDK16_HUMAN (1-496): 2.61e-178: 511: 100.00
+	Hs
		909449 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67
+	Hs
		904447 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67
+	Hs
		625306 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Hs
		625296 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Hs
		909447 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06
+	Hs
		909472 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CDK18_HUMAN (1-490): 5.61e-137: 405: 61.84
+	Hs
		625383 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Dm
		955007 1433E_DROME (1-243): 1.58e-140: 396: 63.37		Q7KM03_DROME (4-479): 4.35e-136: 404: 43.81
+	Dm
		955011 1433E_DROME (1-243): 1.58e-140: 396: 63.37		Q94888_DROME (4-479): 1.48e-135: 402: 44.47
+	Hs
		904478 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CDK18_HUMAN (1-490): 5.61e-137: 405: 61.84
+	Hs
		960082 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06
+	At
		965298 14332_ARATH (4-244): 1.39e-141: 398: 61.32		MPK7_ARATH (152-490): 6.63e-132: 388: 31.79
+	Hs
		300632 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		841132 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69
+	Hs
		300631 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		841128 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69
+	Hs
		300636 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		841174 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69