HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 1052
+	Hs
		909560 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		FAK2_HUMAN (35-1043): 0: 852: 44.78
+	Hs
		201290 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16
+	Xl
		223344 O57468_XENLA (1-244): 4.25e-141: 397: 63.12		Q804T2_XENLA (367-1026): 6.42e-122: 392: 15.34
+	Hs
		904484 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		ACK1_HUMAN (386-1032): 6.61e-120: 395: 22.90
+	Hs
		647862 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MARK3_HUMAN (367-1026): 1.59e-119: 386: 16.85
+	Mm
		910231 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		MARK3_MOUSE (367-1026): 3.1e-119: 385: 16.78
+	Hs
		373995 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88
+	Hs
		647860 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MARK3_HUMAN (367-1026): 1.59e-119: 386: 16.85
+	Mm
		905331 1433G_MOUSE (1-247): 3.15e-139: 392: 100.00		MARK3_MOUSE (367-1026): 3.1e-119: 385: 16.78
+	Hs
		201312 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16
+	Hs
		373992 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88
+	At
		1280891 14337_ARATH (3-244): 3.18e-142: 400: 60.25		CIPKC_ARATH (398-832): 1.9e-118: 374: 19.61
+	At
		788672 14333_ARATH (1-244): 4.4e-142: 400: 61.79		CIPKC_ARATH (398-832): 1.9e-118: 374: 19.61
+	At
		965360 14332_ARATH (4-244): 1.39e-141: 398: 61.32		CIPKC_ARATH (398-832): 1.9e-118: 374: 19.61
+	Mm
		935481 1433F_MOUSE (1-246): 1.51e-136: 385: 86.99		MARK3_MOUSE (367-1026): 3.1e-119: 385: 16.78
+	Hs
		647879 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		MARK3_HUMAN (367-1026): 1.59e-119: 386: 16.85
+	Hs
		374091 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		RAF1_HUMAN (106-714): 1.08e-119: 383: 16.88
+	Mm
		905358 1433G_MOUSE (1-247): 3.15e-139: 392: 100.00		RAF1_MOUSE (217-714): 6.91e-115: 371: 18.11
+	Hs
		411661 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		LCK_HUMAN (412-691): 7.42e-111: 355: 37.37
+	Hs
		909589 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		ERBB4_HUMAN (408-695): 1.19e-58: 222: 39.53