HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: PAK2 (Q13177)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Gene: PAK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006469 - negative regulation of protein kinase activity GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 524
+	Hs
		904514 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63
+	At
		965291 14332_ARATH (4-244): 1.39e-141: 398: 61.32		CDPK1_ARATH (93-523): 3.27e-132: 398: 21.82
+	Hs
		681770 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		AKT1_HUMAN (141-523): 1.99e-133: 397: 21.83
+	At
		802001 14334_ARATH (4-244): 5e-140: 395: 60.91		CDPK1_ARATH (93-523): 3.27e-132: 398: 21.82
+	At
		1280891 14337_ARATH (3-244): 3.18e-142: 400: 60.25		CIPKC_ARATH (229-503): 1.65e-131: 392: 28.83
+	At
		788672 14333_ARATH (1-244): 4.4e-142: 400: 61.79		CIPKC_ARATH (229-503): 1.65e-131: 392: 28.83
+	At
		965360 14332_ARATH (4-244): 1.39e-141: 398: 61.32		CIPKC_ARATH (229-503): 1.65e-131: 392: 28.83
+	Hs
		681766 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		AKT1_HUMAN (141-523): 1.99e-133: 397: 21.83
+	Hs
		568616 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91
+	At
		788694 14335_ARATH (3-244): 5.67e-136: 385: 59.02		CDPK1_ARATH (93-523): 3.27e-132: 398: 21.82
+	Hs
		909512 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		STK3_HUMAN (224-524): 1.89e-125: 377: 41.25
+	Hs
		909502 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		STK4_HUMAN (221-518): 9.32e-125: 375: 40.00
+	Hs
		904517 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		STK3_HUMAN (224-524): 1.89e-125: 377: 41.25
+	Hs
		904507 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		STK4_HUMAN (221-518): 9.32e-125: 375: 40.00
+	Hs
		910114 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		PAK5_HUMAN (67-179): 3.87e-12: 70.7: 25.64
+	Hs
		910063 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		PAK6_HUMAN (65-127): 1.59e-10: 65.7: 38.10
+	Hs
		330944 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55
+	Hs
		905206 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PAK5_HUMAN (67-179): 3.87e-12: 70.7: 25.64
+	Hs
		905151 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PAK6_HUMAN (65-127): 1.59e-10: 65.7: 38.10
+	Hs
		330938 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55