HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: KCC2D (Q13557)
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Gene: CAMK2D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	32873725
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 499
+	Hs
		909531 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KCC2G_HUMAN (1-478): 0: 646: 75.45
+	Hs
		904531 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		KCC2G_HUMAN (1-478): 0: 646: 75.45
+	Hs
		981988 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		KCC2G_HUMAN (1-478): 0: 646: 75.45
+	Hs
		909532 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KCC2D_HUMAN (1-499): 0: 606: 100.00
+	Hs
		683326 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		KCC2G_HUMAN (1-478): 0: 646: 75.45
+	Hs
		927014 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		KCC2G_HUMAN (1-478): 0: 646: 75.45
+	Hs
		910174 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KCC2A_HUMAN (1-474): 0: 541: 87.37
+	Mm
		926819 1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59		KCC2D_MOUSE (1-499): 0: 606: 100.00
+	Hs
		684020 1433S_HUMAN (2-245): 1.86e-98: 289: 65.16		KCC2D_HUMAN (1-499): 0: 606: 100.00
+	Hs
		683826 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		KCC2A_HUMAN (1-474): 0: 541: 87.37
+	Mm
		515221 1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59		KCC2A_MOUSE (1-474): 0: 542: 87.58
+	At
		965291 14332_ARATH (4-244): 1.39e-141: 398: 61.32		CDPK1_ARATH (4-442): 2.61e-154: 454: 28.23
+	At
		802001 14334_ARATH (4-244): 5e-140: 395: 60.91		CDPK1_ARATH (4-442): 2.61e-154: 454: 28.23
+	Mm
		926866 1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59		KCC2G_MOUSE (1-478): 0: 532: 79.58
+	Hs
		647391 1433T_HUMAN (2-245): 5.53e-105: 305: 70.33		KCC2A_HUMAN (1-474): 0: 541: 87.37
+	At
		788694 14335_ARATH (3-244): 5.67e-136: 385: 59.02		CDPK1_ARATH (4-442): 2.61e-154: 454: 28.23
+	Hs
		684406 1433S_HUMAN (2-245): 1.86e-98: 289: 65.16		KCC2A_HUMAN (1-474): 0: 541: 87.37
+	Hs
		159186 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CSKP_HUMAN (10-308): 1.58e-88: 292: 47.71
+	Hs
		683325 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		KCC2B_HUMAN (228-478): 1.5e-64: 223: 50.20
+	Mm
		659446 1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59		KCC2B_MOUSE (321-478): 1.32e-51: 185: 79.75