HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: TESK1 (Q15569)
Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1)
Gene: TESK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 626
+	Hs
		909593 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		TESK1_HUMAN (1-626): 4.8e-177: 518: 100.00
+	Hs
		982038 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		TESK1_HUMAN (1-626): 4.8e-177: 518: 100.00
+	Hs
		683370 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		TESK1_HUMAN (1-626): 4.8e-177: 518: 100.00
+	Hs
		909940 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		TESK2_HUMAN (34-501): 3.55e-140: 421: 50.85
+	Hs
		905019 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		TESK2_HUMAN (34-501): 3.55e-140: 421: 50.85
+	Hs
		684054 1433S_HUMAN (2-245): 1.86e-98: 289: 65.16		TESK1_HUMAN (1-626): 4.8e-177: 518: 100.00
+	Hs
		982411 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		TESK2_HUMAN (34-501): 3.55e-140: 421: 50.85
+	At
		965327 14332_ARATH (4-244): 1.39e-141: 398: 61.32		PBS1_ARATH (5-404): 2.55e-128: 387: 21.97
+	At
		788521 14333_ARATH (1-244): 4.4e-142: 400: 61.79		PBL9_ARATH (12-369): 3.1e-126: 380: 23.27
+	Hs
		201290 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		M3K7_HUMAN (50-541): 1.23e-119: 370: 21.89
+	Hs
		201312 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		M3K7_HUMAN (50-541): 1.23e-119: 370: 21.89
+	Hs
		683647 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		TESK2_HUMAN (34-501): 3.55e-140: 421: 50.85
+	Hs
		927432 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		TESK2_HUMAN (34-501): 3.55e-140: 421: 50.85
+	Hs
		647209 1433T_HUMAN (2-245): 5.53e-105: 305: 70.33		TESK2_HUMAN (34-501): 3.55e-140: 421: 50.85
+	Hs
		863816 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		LIMK2_HUMAN (16-342): 5.04e-101: 322: 39.21
+	Hs
		684284 1433S_HUMAN (2-245): 1.86e-98: 289: 65.16		TESK2_HUMAN (34-501): 3.55e-140: 421: 50.85
+	Hs
		683917 1433S_HUMAN (2-245): 1.86e-98: 289: 65.16		LIMK2_HUMAN (16-342): 5.04e-101: 322: 39.21
+	Hs
		863759 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		LIMK1_HUMAN (10-324): 1.13e-59: 212: 39.27
+	Hs
		863760 1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59		LIMK1_HUMAN (10-324): 1.13e-59: 212: 39.27
+	Hs
		683916 1433S_HUMAN (2-245): 1.86e-98: 289: 65.16		LIMK1_HUMAN (10-324): 1.13e-59: 212: 39.27