HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	33961781, 35271311, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 1919
+	Hs
		909845 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Hs
		982311 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Hs
		683563 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Mm
		910260 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Mm
		905344 1433G_MOUSE (1-247): 3.15e-139: 392: 100.00		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Dm
		677686 1433E_DROME (1-243): 1.58e-140: 396: 63.37		DLG1_DROME (1123-1916): 3.18e-132: 441: 20.16
+	Hs
		280039 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MPDZ_HUMAN (1405-1909): 9.74e-18: 92.7: 11.22
+	Hs
		280040 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		MPDZ_HUMAN (1405-1909): 9.74e-18: 92.7: 11.22
+	Hs
		910124 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		909488 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		CGNL1_HUMAN (145-628): 2.87e-10: 67.8: 21.72
+	Hs
		905218 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		904495 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		CGNL1_HUMAN (145-628): 2.87e-10: 67.8: 21.72
+	Hs
		904480 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81
+	Hs
		982588 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		981958 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		CGNL1_HUMAN (145-628): 2.87e-10: 67.8: 21.72
+	Mm
		935715 1433F_MOUSE (1-246): 1.51e-136: 385: 86.99		ZO2_MOUSE (1494-1740): 3.46e-09: 64.3: 9.38
+	Hs
		981947 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81
+	Hs
		683788 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		683298 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		CGNL1_HUMAN (145-628): 2.87e-10: 67.8: 21.72
+	Hs
		683290 1433B_HUMAN (2-247): 1.91e-109: 317: 75.40		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81