HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: PI3R4 (Q99570)
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)
Gene: PIK3R4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36931259, 17353931
Identification Methods	proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane GO:0042149 - cellular response to glucose starvation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 1358
+	Hs
		909952 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		PI3R4_HUMAN (1-1358): 0: 1154: 100.00
+	Hs
		910013 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		SIK2_HUMAN (10-996): 3.01e-151: 483: 12.43
+	Hs
		905098 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		SIK2_HUMAN (10-996): 3.01e-151: 483: 12.43
+	At
		1280891 14337_ARATH (3-244): 3.18e-142: 400: 60.25		CIPKC_ARATH (1-491): 3.68e-113: 366: 15.32
+	At
		788672 14333_ARATH (1-244): 4.4e-142: 400: 61.79		CIPKC_ARATH (1-491): 3.68e-113: 366: 15.32
+	At
		965360 14332_ARATH (4-244): 1.39e-141: 398: 61.32		CIPKC_ARATH (1-491): 3.68e-113: 366: 15.32
+	Mm
		935611 1433F_MOUSE (1-246): 1.51e-136: 385: 86.99		PLRG1_MOUSE (774-1358): 6.78e-113: 366: 13.78
+	Hs
		909532 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91
+	Hs
		904532 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91
+	Hs
		910174 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KCC2A_HUMAN (24-470): 2.2e-98: 325: 15.35
+	At
		965300 14332_ARATH (4-244): 1.39e-141: 398: 61.32		PRL2_ARATH (811-1289): 1.52e-83: 284: 15.46
+	Mm
		910266 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		NUAK1_MOUSE (2-311): 1.93e-75: 266: 21.56
+	Hs
		229938 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20
+	Hs
		229936 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20
+	Hs
		229942 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20
+	Hs
		910009 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		NUAK2_HUMAN (7-311): 1.51e-67: 242: 18.91
+	Hs
		883214 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		SIK1_HUMAN (26-333): 4.95e-60: 224: 17.98
+	Hs
		883212 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		SIK1_HUMAN (26-333): 4.95e-60: 224: 17.98
+	Hs
		883218 1433F_HUMAN (1-246): 2.5e-135: 382: 86.99		SIK1_HUMAN (26-333): 4.95e-60: 224: 17.98
+	At
		788540 14333_ARATH (1-244): 4.4e-142: 400: 61.79		PRL1_ARATH (761-1189): 1.23e-13: 77.2: 12.47