HitPredict

Interactor 1: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Interactor 2: M4K5 (Q9Y4K4)
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)
Gene: MAP4K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 247 Hs			1 846
+	Hs
		909881 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		M4K1_HUMAN (9-845): 0: 774: 44.52
+	Hs
		909532 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KCC2D_HUMAN (8-517): 1.77e-144: 437: 18.38
+	Dm
		90534 1433E_DROME (1-243): 1.58e-140: 396: 63.37		E1JGN0_DROME (4-616): 3.67e-136: 435: 18.02
+	Hs
		909567 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MELK_HUMAN (20-615): 3.46e-137: 424: 19.44
+	Hs
		647862 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MARK3_HUMAN (13-559): 3.08e-135: 422: 18.71
+	Mm
		910231 1433E_MOUSE (1-244): 2.02e-141: 398: 63.53		MARK3_MOUSE (13-559): 6.4e-135: 421: 18.88
+	Hs
		910174 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		KCC2A_HUMAN (8-488): 3.27e-138: 420: 19.26
+	Hs
		647860 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		MARK3_HUMAN (13-559): 3.08e-135: 422: 18.71
+	Mm
		905331 1433G_MOUSE (1-247): 3.15e-139: 392: 100.00		MARK3_MOUSE (13-559): 6.4e-135: 421: 18.88
+	Xl
		223344 O57468_XENLA (1-244): 4.25e-141: 397: 63.12		Q804T2_XENLA (17-489): 4.52e-126: 397: 21.01
+	Hs
		909730 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MARK2_HUMAN (2-473): 3.58e-124: 394: 21.36
+	At
		1280891 14337_ARATH (3-244): 3.18e-142: 400: 60.25		CIPKC_ARATH (2-385): 5.32e-125: 386: 26.09
+	At
		788672 14333_ARATH (1-244): 4.4e-142: 400: 61.79		CIPKC_ARATH (2-385): 5.32e-125: 386: 26.09
+	Hs
		681770 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	At
		965360 14332_ARATH (4-244): 1.39e-141: 398: 61.32		CIPKC_ARATH (2-385): 5.32e-125: 386: 26.09
+	Hs
		909502 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		STK4_HUMAN (10-278): 1.36e-120: 375: 45.93
+	Hs
		909512 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		STK3_HUMAN (1-408): 2.41e-120: 374: 32.45
+	Hs
		909810 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		MINK1_HUMAN (3-295): 3.13e-70: 254: 45.28
+	Hs
		324772 1433E_HUMAN (1-244): 2.02e-141: 398: 63.53		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51
+	Hs
		324769 1433G_HUMAN (1-247): 3.15e-139: 392: 100.00		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51