HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.762

Property	Details
Experiments	24366813, 23088536, 32296183, 26186194, 27880917, 28514442, 28330616, 29669786, 33961781, 22321011, 21189257, 15231748, 21998301
Identification Methods	affinity chromatography technology, pull down, two hybrid, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007049 - cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 1128
+	Mm
		93784 PP1A_MOUSE (1-330): 0: 614: 99.70		E9QJU8_MOUSE (1-1128): 0: 576: 90.79
+	Hs
		737795 PP1G_HUMAN (1-330): 0: 579: 90.66		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		905849 PP1A_HUMAN (1-330): 0: 614: 100.00		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Hs
		737760 PP1G_HUMAN (1-330): 0: 579: 90.66		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Mm
		906278 PP1A_MOUSE (1-330): 0: 614: 99.70		ASPP1_MOUSE (1-1128): 5.97e-136: 441: 45.12
+	Hs
		906081 PP1A_HUMAN (1-330): 0: 614: 100.00		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Mm
		906260 PP1A_MOUSE (1-330): 0: 614: 99.70		IASPP_MOUSE (390-1127): 9.81e-55: 207: 22.17
+	Hs
		906042 PP1A_HUMAN (1-330): 0: 614: 100.00		IASPP_HUMAN (416-1127): 1.13e-53: 204: 21.65
+	Hs
		906000 PP1A_HUMAN (1-330): 0: 614: 100.00		PPR27_HUMAN (920-1036): 9.87e-38: 140: 32.20
+	Hs
		906079 PP1A_HUMAN (1-330): 0: 614: 100.00		PP16A_HUMAN (939-1037): 6.43e-21: 99: 33.33
+	Hs
		906099 PP1A_HUMAN (1-330): 0: 614: 100.00		PP16B_HUMAN (945-1037): 1.27e-19: 96.1: 36.56
+	Hs
		161347 PP1A_HUMAN (1-330): 0: 614: 100.00		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89
+	Mm
		906366 PP1A_MOUSE (1-330): 0: 614: 99.70		MYPT1_MOUSE (891-1059): 3.49e-16: 86: 26.74
+	Mm
		906252 PP1A_MOUSE (1-330): 0: 614: 99.70		PP12C_MOUSE (906-1036): 3.9e-13: 76: 24.27
+	Mm
		906293 PP1A_MOUSE (1-330): 0: 614: 99.70		MYPT2_MOUSE (947-1035): 2.73e-12: 73.3: 33.71
+	Hs
		906116 PP1A_HUMAN (1-330): 0: 614: 100.00		PP12C_HUMAN (906-1034): 4.04e-12: 72.6: 23.88
+	Hs
		225132 PP1A_HUMAN (1-330): 0: 614: 100.00		MYPT2_HUMAN (947-1035): 1.24e-11: 71.4: 33.71
+	Hs
		161322 PP1G_HUMAN (1-330): 0: 579: 90.66		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89
+	Mm
		926555 PP1G_MOUSE (1-330): 0: 579: 90.66		MYPT1_MOUSE (891-1059): 3.49e-16: 86: 26.74
+	Hs
		225129 PP1G_HUMAN (1-330): 0: 579: 90.66		MYPT2_HUMAN (947-1035): 1.24e-11: 71.4: 33.71