HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 27880917, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, PDZ~STPPase_N
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0070062 - extracellular exosome GO:0098793 - presynapse and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 1630
+	Hs
		737799 PP1G_HUMAN (1-330): 0: 579: 90.66		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		906454 PP1B_HUMAN (1-330): 0: 568: 87.88		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		906202 PP1A_HUMAN (1-330): 0: 614: 100.00		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		738129 PP1G_HUMAN (1-330): 0: 579: 90.66		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		906638 PP1B_HUMAN (1-330): 0: 568: 87.88		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		906110 PP1A_HUMAN (1-330): 0: 614: 100.00		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Mm
		906292 PP1A_MOUSE (1-330): 0: 614: 99.70		LRRC1_MOUSE (1-277): 1e-67: 240: 32.49
+	Dm
		524646 PP12_DROME (7-304): 0: 553: 93.29		SUR8_DROME (85-565): 1.98e-85: 295: 23.77
+	Hs
		738009 PP1G_HUMAN (1-330): 0: 579: 90.66		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Hs
		906581 PP1B_HUMAN (1-330): 0: 568: 87.88		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Mm
		906274 PP1A_MOUSE (1-330): 0: 614: 99.70		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Dm
		524622 PP12_DROME (7-304): 0: 553: 93.29		SCRIB_DROME (1-258): 6.81e-66: 249: 37.98
+	Mm
		906652 PP1B_MOUSE (1-330): 0: 568: 87.88		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Hs
		905921 PP1A_HUMAN (1-330): 0: 614: 100.00		DLG2_HUMAN (587-879): 1.21e-20: 101: 18.67
+	Hs
		906059 PP1A_HUMAN (1-330): 0: 614: 100.00		DLG3_HUMAN (724-947): 1.74e-19: 97.4: 31.23
+	Hs
		906094 PP1A_HUMAN (1-330): 0: 614: 100.00		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Mm
		915328 PP2AB_MOUSE (8-302): 1.41e-176: 492: 47.97		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Mm
		926531 PP1G_MOUSE (1-330): 0: 579: 90.66		DLG3_MOUSE (724-947): 3.57e-19: 96.3: 31.23
+	Hs
		737775 PP1G_HUMAN (1-330): 0: 579: 90.66		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		737994 PP1G_HUMAN (1-330): 0: 579: 90.66		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06