HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: PP1R7 (Q15435)
Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22)
Gene: PPP1R7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.977

Property	Details
Experiments	27880917, 27173435, 28330616, 29669786, 31548429, 26186194, 28514442, 33961781, 25593058
Identification Methods	affinity chromatography technology, proximity labelling technology, x-ray crystallography, pull down, tandem affinity purification, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	LRR_9~Metallophos, LRR_9~STPPase_N
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 360
+	Mm
		906251 PP1A_MOUSE (1-330): 0: 614: 99.70		PP1R7_MOUSE (1-360): 1.22e-55: 187: 93.35
+	Hs
		737822 PP1G_HUMAN (1-330): 0: 579: 90.66		PP1R7_HUMAN (1-360): 8.35e-58: 193: 100.00
+	Hs
		906470 PP1B_HUMAN (1-330): 0: 568: 87.88		PP1R7_HUMAN (1-360): 8.35e-58: 193: 100.00
+	Hs
		905890 PP1A_HUMAN (1-330): 0: 614: 100.00		SCRIB_HUMAN (110-360): 8.96e-32: 128: 19.38
+	Sp
		605293 PP12_SCHPO (8-303): 0: 538: 79.73		SDS22_SCHPO (93-358): 1.22e-54: 184: 50.00
+	Hs
		737799 PP1G_HUMAN (1-330): 0: 579: 90.66		SCRIB_HUMAN (110-360): 8.96e-32: 128: 19.38
+	Hs
		906094 PP1A_HUMAN (1-330): 0: 614: 100.00		ERBIN_HUMAN (24-160): 1.95e-18: 89.1: 14.11
+	Dm
		819228 PP11_DROME (4-330): 0: 573: 87.77		Q9VEK8_DROME (124-360): 2e-32: 125: 36.71
+	Hs
		906454 PP1B_HUMAN (1-330): 0: 568: 87.88		SCRIB_HUMAN (110-360): 8.96e-32: 128: 19.38
+	Ca
		1124021 Q59N42_CANAL (3-330): 0: 561: 81.40		Q5AHH6_CANAL (53-266): 1.98e-35: 134: 30.73
+	Hs
		905863 PP1A_HUMAN (1-330): 0: 614: 100.00		FLII_HUMAN (230-360): 4.87e-13: 72.5: 16.67
+	Dm
		524647 PP12_DROME (7-304): 0: 553: 93.29		Q9VEK8_DROME (124-360): 2e-32: 125: 36.71
+	Dm
		819306 PP1B_DROME (6-326): 0: 551: 83.49		Q9VEK8_DROME (124-360): 2e-32: 125: 36.71
+	Dm
		984195 PP13_DROME (5-304): 0: 550: 91.67		Q9VEK8_DROME (124-360): 2e-32: 125: 36.71
+	Sc
		696298 PP12_YEAST (3-307): 0: 551: 84.26		SDS22_YEAST (19-287): 1.88e-31: 123: 29.60
+	Hs
		737994 PP1G_HUMAN (1-330): 0: 579: 90.66		ERBIN_HUMAN (24-160): 1.95e-18: 89.1: 14.11
+	Dm
		524622 PP12_DROME (7-304): 0: 553: 93.29		SCRIB_DROME (132-360): 5.73e-27: 114: 18.82
+	Hs
		737779 PP1G_HUMAN (1-330): 0: 579: 90.66		FLII_HUMAN (230-360): 4.87e-13: 72.5: 16.67
+	Hs
		906437 PP1B_HUMAN (1-330): 0: 568: 87.88		FLII_HUMAN (230-360): 4.87e-13: 72.5: 16.67
+	Ce
		800282 GLC7A_CAEEL (1-320): 0: 555: 84.57		SDS22_CAEEL (18-176): 2.37e-10: 62.9: 22.22