HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: PHAR3 (Q96KR7)
Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin)
Gene: PHACTR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.682

Property	Details
Experiments	28330616, 12925532, 22321011
Identification Methods	affinity chromatography technology, far western blotting, two hybrid, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 559
+	Hs
		737982 PP1G_HUMAN (1-330): 0: 579: 90.66		PHAR3_HUMAN (1-559): 0: 646: 100.00
+	Hs
		906118 PP1A_HUMAN (1-330): 0: 614: 100.00		PHAR1_HUMAN (12-559): 0: 609: 42.45
+	Hs
		906563 PP1B_HUMAN (1-330): 0: 568: 87.88		PHAR3_HUMAN (1-559): 0: 646: 100.00
+	Mm
		69836 PP1A_MOUSE (1-330): 0: 614: 99.70		B1AVP0_MOUSE (40-262): 6.45e-55: 197: 26.29
+	Hs
		906013 PP1A_HUMAN (1-330): 0: 614: 100.00		PHAR4_HUMAN (34-246): 2.73e-35: 142: 26.03
+	Hs
		737916 PP1G_HUMAN (1-330): 0: 579: 90.66		PHAR4_HUMAN (34-246): 2.73e-35: 142: 26.03
+	Dm
		524625 PP12_DROME (7-304): 0: 553: 93.29		Q8IH02_DROME (46-235): 9.11e-42: 158: 27.75