HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	38280479, 21189257, 26116754
Identification Methods	proximity labelling technology, affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 400
+	Hs
		808454 PP1A_HUMAN (1-330): 0: 614: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		737645 PP1G_HUMAN (1-330): 0: 579: 90.66		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		808455 PP1B_HUMAN (1-330): 0: 568: 87.88		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		125313 PP1A_HUMAN (1-330): 0: 614: 100.00		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		808496 PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.30		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		125314 PP1B_HUMAN (1-330): 0: 568: 87.88		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		906167 PP1A_HUMAN (1-330): 0: 614: 100.00		WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09
+	Hs
		931006 PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.30		SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62