HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: SH24A (Q9H788)
SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)
Gene: SH2D4A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.681

Property	Details
Experiments	28514442, 33961781, 19389623
Identification Methods	affinity chromatography technology, far western blotting, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 454
+	Hs
		738050 PP1G_HUMAN (1-330): 0: 579: 90.66		SH24A_HUMAN (1-454): 1.2e-138: 407: 100.00
+	Hs
		906600 PP1B_HUMAN (1-330): 0: 568: 87.88		SH24A_HUMAN (1-454): 1.2e-138: 407: 100.00
+	Hs
		905820 PP1A_HUMAN (1-330): 0: 614: 100.00		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Hs
		737723 PP1G_HUMAN (1-330): 0: 579: 90.66		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Hs
		111444 PP1B_HUMAN (1-330): 0: 568: 87.88		J3QRU1_HUMAN (200-454): 4.85e-42: 158: 15.39
+	Hs
		433310 PP1B_HUMAN (1-330): 0: 568: 87.88		YES_HUMAN (201-454): 1.68e-41: 156: 15.44
+	Hs
		906402 PP1B_HUMAN (1-330): 0: 568: 87.88		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Mm
		906650 PP1B_MOUSE (1-330): 0: 568: 87.88		GRB2_MOUSE (310-454): 9.77e-43: 151: 24.83
+	Hs
		796535 PP1A_HUMAN (1-330): 0: 614: 100.00		KSYK_HUMAN (273-440): 2.84e-14: 76.8: 23.08
+	Hs
		522884 PP2AB_HUMAN (8-302): 1.41e-176: 492: 47.97		SRC_HUMAN (238-454): 4.15e-42: 158: 14.56
+	Hs
		796542 PP2AA_HUMAN (8-302): 3.14e-176: 492: 47.30		KSYK_HUMAN (273-440): 2.84e-14: 76.8: 23.08