HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: NEB1 (Q9ULJ8)
Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A)
Gene: PPP1R9A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.932

Property	Details
Experiments	26186194, 27880917, 28514442, 28330616, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, Metallophos~PDZ_5, PDZ~STPPase_N, PDZ_5~STPPase_N
Common GO terms	GO:0005737 - cytoplasm GO:0043197 - dendritic spine
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 330 Hs			1 1098
+	Hs
		738120 PP1G_HUMAN (1-330): 0: 579: 90.66		NEB1_HUMAN (1-1098): 6.8e-118: 392: 100.00
+	Hs
		906629 PP1B_HUMAN (1-330): 0: 568: 87.88		NEB1_HUMAN (1-1098): 6.8e-118: 392: 100.00
+	Rn
		193534 PP1G_RAT (1-330): 0: 579: 90.66		NEB1_RAT (1-1093): 2.67e-113: 379: 90.04
+	Rn
		193533 PP1B_RAT (1-330): 0: 568: 87.88		NEB1_RAT (1-1093): 2.67e-113: 379: 90.04
+	Hs
		906059 PP1A_HUMAN (1-330): 0: 614: 100.00		DLG3_HUMAN (311-1098): 1.22e-71: 257: 13.03
+	Mm
		926531 PP1G_MOUSE (1-330): 0: 579: 90.66		DLG3_MOUSE (311-1098): 3.85e-70: 253: 13.06
+	Hs
		737775 PP1G_HUMAN (1-330): 0: 579: 90.66		DLG1_HUMAN (225-1097): 2.22e-67: 246: 13.80
+	Hs
		905921 PP1A_HUMAN (1-330): 0: 614: 100.00		DLG2_HUMAN (116-922): 4.42e-55: 209: 12.95
+	Mm
		906274 PP1A_MOUSE (1-330): 0: 614: 99.70		DLG4_MOUSE (376-1098): 3.11e-50: 192: 13.00
+	Rn
		192519 PP1A_RAT (1-330): 0: 614: 100.00		NEB2_RAT (1-826): 2.53e-45: 178: 43.42
+	Mm
		906288 PP1A_MOUSE (1-330): 0: 614: 99.70		NEB2_MOUSE (1-826): 5.97e-43: 171: 43.42
+	Hs
		906098 PP1A_HUMAN (1-330): 0: 614: 100.00		NEB2_HUMAN (1-826): 1.2e-42: 170: 43.65
+	Mm
		906652 PP1B_MOUSE (1-330): 0: 568: 87.88		DLG4_MOUSE (376-1098): 3.11e-50: 192: 13.00
+	Rn
		192521 PP1G_RAT (1-330): 0: 579: 90.66		NEB2_RAT (1-826): 2.53e-45: 178: 43.42
+	Mm
		926545 PP1G_MOUSE (1-330): 0: 579: 90.66		NEB2_MOUSE (1-826): 5.97e-43: 171: 43.42
+	Hs
		737997 PP1G_HUMAN (1-330): 0: 579: 90.66		NEB2_HUMAN (1-826): 1.2e-42: 170: 43.65
+	Rn
		192520 PP1B_RAT (1-330): 0: 568: 87.88		NEB2_RAT (1-826): 2.53e-45: 178: 43.42
+	Mm
		906654 PP1B_MOUSE (1-330): 0: 568: 87.88		NEB2_MOUSE (1-826): 5.97e-43: 171: 43.42
+	Hs
		906570 PP1B_HUMAN (1-330): 0: 568: 87.88		NEB2_HUMAN (1-826): 1.2e-42: 170: 43.65
+	Hs
		528366 PP1A_HUMAN (1-330): 0: 614: 100.00		MYH6_HUMAN (574-1090): 1.43e-15: 84.4: 11.28