HitPredict

Interactor 1: PP1A (P62136)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Gene: PPP1CA

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	26186194, 28514442, 28330616, 31738558, 29669786
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007049 - cell cycle GO:0051301 - cell division and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 330 Hs			1 456
+	Mm
		888047 PP1A_MOUSE (1-330): 0: 614: 99.70		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Hs
		738135 PP1G_HUMAN (1-330): 0: 579: 90.66		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		906205 PP1A_HUMAN (1-330): 0: 614: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Mm
		906384 PP1A_MOUSE (1-330): 0: 614: 99.70		RUVB2_MOUSE (2-455): 0: 651: 42.76
+	Hs
		738134 PP1G_HUMAN (1-330): 0: 579: 90.66		RUVB2_HUMAN (2-455): 0: 651: 42.76