HitPredict

Interactor 1: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	27880917
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, PDZ~STPPase_N
Common GO terms	GO:0005654 - nucleoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 327 Hs			1 1630
+	Hs
		905890 PP1A_HUMAN (1-326): 0: 576: 88.79		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		737799 PP1G_HUMAN (1-327): 0: 569: 86.89		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		906638 PP1B_HUMAN (1-327): 0: 597: 100.00		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		906202 PP1A_HUMAN (1-326): 0: 576: 88.79		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		738129 PP1G_HUMAN (1-327): 0: 569: 86.89		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		906581 PP1B_HUMAN (1-327): 0: 597: 100.00		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Dm
		524646 PP12_DROME (6-303): 0: 546: 88.59		SUR8_DROME (85-565): 1.98e-85: 295: 23.77
+	Hs
		906110 PP1A_HUMAN (1-326): 0: 576: 88.79		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Hs
		738009 PP1G_HUMAN (1-327): 0: 569: 86.89		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Mm
		906292 PP1A_MOUSE (1-326): 0: 576: 88.49		LRRC1_MOUSE (1-277): 1e-67: 240: 32.49
+	Dm
		524622 PP12_DROME (6-303): 0: 546: 88.59		SCRIB_DROME (1-258): 6.81e-66: 249: 37.98
+	Mm
		906652 PP1B_MOUSE (1-327): 0: 597: 100.00		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Mm
		906274 PP1A_MOUSE (1-326): 0: 576: 88.49		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Mm
		915328 PP2AB_MOUSE (8-303): 1.26e-176: 492: 46.13		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Hs
		905921 PP1A_HUMAN (1-326): 0: 576: 88.79		DLG2_HUMAN (587-879): 1.21e-20: 101: 18.67
+	Hs
		906059 PP1A_HUMAN (1-326): 0: 576: 88.79		DLG3_HUMAN (724-947): 1.74e-19: 97.4: 31.23
+	Mm
		926531 PP1G_MOUSE (1-327): 0: 569: 86.89		DLG3_MOUSE (724-947): 3.57e-19: 96.3: 31.23
+	Hs
		737775 PP1G_HUMAN (1-327): 0: 569: 86.89		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		906094 PP1A_HUMAN (1-326): 0: 576: 88.79		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Hs
		737994 PP1G_HUMAN (1-327): 0: 569: 86.89		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06