HitPredict

Interactor 1: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Interactor 2: ASPP1 (Q96KQ4)
Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)
Gene: PPP1R13B

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	27880917, 28330616, 24366813, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 327 Hs			1 1090
+	Hs
		906447 PP1B_HUMAN (1-327): 0: 597: 100.00		ASPP2_HUMAN (1-1090): 2e-141: 456: 46.13
+	Mm
		906278 PP1A_MOUSE (1-326): 0: 576: 88.49		ASPP1_MOUSE (1-1090): 2.37e-147: 471: 91.38
+	Mm
		93784 PP1A_MOUSE (1-326): 0: 576: 88.49		E9QJU8_MOUSE (1-1090): 1.84e-134: 437: 45.87
+	Hs
		906424 PP1B_HUMAN (1-327): 0: 597: 100.00		Q05BL1_HUMAN (91-1090): 6.16e-104: 353: 44.56
+	Hs
		906542 PP1B_HUMAN (1-327): 0: 597: 100.00		DOT1L_HUMAN (94-844): 1.19e-72: 266: 16.97
+	Hs
		906543 PP1B_HUMAN (1-327): 0: 597: 100.00		IASPP_HUMAN (336-1089): 6.59e-57: 214: 22.46
+	Mm
		906260 PP1A_MOUSE (1-326): 0: 576: 88.49		IASPP_MOUSE (292-1089): 1.39e-55: 210: 22.35
+	Hs
		3260 PP1B_HUMAN (1-327): 0: 597: 100.00		A0A0S2Z4Q8_HUMAN (855-1017): 7.3e-47: 167: 29.45
+	Hs
		225133 PP1B_HUMAN (1-327): 0: 597: 100.00		MYPT2_HUMAN (857-997): 1.8e-38: 158: 32.62
+	Hs
		225132 PP1A_HUMAN (1-326): 0: 576: 88.79		MYPT2_HUMAN (857-997): 1.8e-38: 158: 32.62
+	Hs
		906517 PP1B_HUMAN (1-327): 0: 597: 100.00		PPR27_HUMAN (882-998): 9.69e-27: 109: 30.51
+	Hs
		906561 PP1B_HUMAN (1-327): 0: 597: 100.00		PP16A_HUMAN (901-999): 6.07e-19: 93.8: 35.35
+	Hs
		906572 PP1B_HUMAN (1-327): 0: 597: 100.00		PP16B_HUMAN (907-999): 1.89e-17: 89.1: 38.71
+	Hs
		161348 PP1B_HUMAN (1-327): 0: 597: 100.00		MYPT1_HUMAN (821-1021): 1.28e-14: 81.1: 24.27
+	Gg
		907234 PP1B_CHICK (1-327): 0: 597: 100.00		MYPT1_CHICK (821-1021): 2.56e-14: 79.9: 24.76
+	Hs
		906585 PP1B_HUMAN (1-327): 0: 597: 100.00		PP12C_HUMAN (921-996): 2.71e-09: 63.3: 31.58
+	Hs
		161347 PP1A_HUMAN (1-326): 0: 576: 88.79		MYPT1_HUMAN (821-1021): 1.28e-14: 81.1: 24.27
+	Mm
		906366 PP1A_MOUSE (1-326): 0: 576: 88.49		MYPT1_MOUSE (821-1021): 3.58e-14: 79.5: 22.82
+	Mm
		906252 PP1A_MOUSE (1-326): 0: 576: 88.49		PP12C_MOUSE (870-998): 4.29e-10: 66: 23.88
+	Mm
		906293 PP1A_MOUSE (1-326): 0: 576: 88.49		MYPT2_MOUSE (921-997): 6.11e-10: 65.6: 32.47