HitPredict

Interactor 1: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Interactor 2: NEB2 (Q96SB3)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: PPP1R9B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	26496610, 10194355, 34591612, 25785436
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, Metallophos~PDZ_5, PDZ~STPPase_N, PDZ_5~STPPase_N
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 327 Hs			1 817
+	Rn
		192520 PP1B_RAT (1-327): 0: 597: 100.00		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Mm
		906654 PP1B_MOUSE (1-327): 0: 597: 100.00		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Hs
		906098 PP1A_HUMAN (1-326): 0: 576: 88.79		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		906629 PP1B_HUMAN (1-327): 0: 597: 100.00		NEB1_HUMAN (1-817): 2.29e-110: 364: 46.47
+	Rn
		192519 PP1A_RAT (1-326): 0: 576: 88.79		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Mm
		906288 PP1A_MOUSE (1-326): 0: 576: 88.49		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Rn
		192521 PP1G_RAT (1-327): 0: 569: 86.89		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Rn
		193533 PP1B_RAT (1-327): 0: 597: 100.00		NEB1_RAT (1-817): 1.22e-104: 349: 46.38
+	Mm
		926545 PP1G_MOUSE (1-327): 0: 569: 86.89		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Hs
		906197 PP1A_HUMAN (1-326): 0: 576: 88.79		NEB1_HUMAN (1-817): 2.29e-110: 364: 46.47
+	Rn
		193534 PP1G_RAT (1-327): 0: 569: 86.89		NEB1_RAT (1-817): 1.22e-104: 349: 46.38
+	Hs
		906059 PP1A_HUMAN (1-326): 0: 576: 88.79		DLG3_HUMAN (154-707): 4.39e-44: 173: 12.27
+	Mm
		926531 PP1G_MOUSE (1-327): 0: 569: 86.89		DLG3_MOUSE (154-707): 1.11e-45: 178: 12.34
+	Hs
		906094 PP1A_HUMAN (1-326): 0: 576: 88.79		ERBIN_HUMAN (11-583): 1.56e-42: 170: 13.02
+	Mm
		906652 PP1B_MOUSE (1-327): 0: 597: 100.00		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Hs
		906031 PP1A_HUMAN (1-326): 0: 576: 88.79		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Hs
		905921 PP1A_HUMAN (1-326): 0: 576: 88.79		DLG2_HUMAN (419-621): 7.73e-28: 122: 20.69
+	Mm
		906274 PP1A_MOUSE (1-326): 0: 576: 88.49		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Hs
		906454 PP1B_HUMAN (1-327): 0: 597: 100.00		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15
+	Hs
		905890 PP1A_HUMAN (1-326): 0: 576: 88.79		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15