HitPredict

Interactor 1: PRS4 (P62191)
26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)
Gene: PSMC1

Interactor 2: PAAF1 (Q9BRP4)
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)
Gene: PAAF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.697

Property	Details
Experiments	17353931, 26496610, 33961781, 15831487
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 392
+	Hs
		913344 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		907142 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		798748 PRS6B_HUMAN (50-433): 1.06e-122: 364: 48.96		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		913238 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		GBB2_HUMAN (64-350): 1.04e-69: 224: 22.56
+	Hs
		792951 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		LIS1_HUMAN (130-391): 7.01e-70: 227: 18.06
+	Hs
		792936 PRS6B_HUMAN (50-433): 1.06e-122: 364: 48.96		LIS1_HUMAN (130-391): 7.01e-70: 227: 18.06
+	Hs
		906981 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		GBB2_HUMAN (64-350): 1.04e-69: 224: 22.56
+	Sc
		744630 PRS4_YEAST (1-440): 2.21e-129: 382: 71.36		TAF5_YEAST (126-391): 8.85e-57: 200: 17.59
+	Sc
		744670 PRS8_YEAST (42-432): 3.07e-122: 363: 44.50		TAF5_YEAST (126-391): 8.85e-57: 200: 17.59
+	Hs
		907118 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		FBXW7_HUMAN (167-390): 5.39e-51: 183: 14.98
+	Sc
		771723 PRS4_YEAST (1-440): 2.21e-129: 382: 71.36		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Sc
		860037 PRS8_YEAST (42-432): 3.07e-122: 363: 44.50		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Sc
		703828 PRS6B_YEAST (60-422): 1.52e-118: 354: 50.28		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Hs
		903094 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Hs
		903081 PRS8_HUMAN (55-433): 1.06e-123: 366: 46.70		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Hs
		798631 PRS6B_HUMAN (50-433): 1.06e-122: 364: 48.96		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Mm
		907215 PRS8_MOUSE (55-433): 1.06e-123: 366: 46.70		PRP19_MOUSE (89-204): 4.15e-13: 72.4: 33.06