HitPredict

Interactor 1: PRS4 (P62191)
26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)
Gene: PSMC1

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	25666615, 30442662, 27114451
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Hs			1 624
+	Hs
		906946 PRS4_HUMAN (1-440): 8.84e-140: 409: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		913364 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		913367 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Dm
		820528 PRS4_DROME (1-440): 1.71e-137: 403: 91.36		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Hs
		906929 PRS4_HUMAN (1-440): 8.84e-140: 409: 100.00		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Dm
		186163 PRS8_DROME (57-433): 1.81e-127: 376: 46.95		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Dm
		1375073 Q9W414_DROME (54-438): 8.04e-125: 369: 40.52		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Dm
		1359420 Q9V405_DROME (35-433): 1.14e-123: 367: 47.87		Q9VWD9_DROME (26-617): 4.15e-130: 395: 44.35
+	Hs
		913358 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	At
		1352317 PRS4A_ARATH (1-440): 1.58e-135: 398: 76.30		DSK2A_ARATH (15-544): 4.66e-86: 280: 27.56
+	Xl
		804064 PRS8_XENLA (55-433): 1.35e-127: 378: 46.44		BAG6A_XENLA (28-578): 4.07e-61: 222: 15.47
+	Hs
		906885 PRS4_HUMAN (1-440): 8.84e-140: 409: 100.00		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		906853 PRS4_HUMAN (1-440): 8.84e-140: 409: 100.00		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Dm
		186166 PRS8_DROME (57-433): 1.81e-127: 376: 46.95		Q9VXF9_DROME (33-313): 1.35e-51: 186: 15.86
+	Hs
		913323 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		913291 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		906808 PRS4_HUMAN (1-440): 8.84e-140: 409: 100.00		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Dm
		820508 PRS4_DROME (1-440): 1.71e-137: 403: 91.36		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Hs
		913240 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		913239 PRS10_HUMAN (66-438): 7.99e-126: 371: 40.75		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27