HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: UBP4 (Q13107)
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)
Gene: USP4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	28514442, 33961781, 23022198
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Prot_ATP_ID_OB~UCH
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 963
+	Hs
		907198 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		UBP15_HUMAN (1-924): 0: 749: 58.17
+	Mm
		907214 PRS8_MOUSE (1-406): 1.42e-136: 398: 100.00		UBP15_MOUSE (1-924): 0: 745: 57.75
+	Mm
		872744 PRS6B_MOUSE (1-399): 8.58e-122: 360: 41.86		UBP15_MOUSE (1-924): 0: 745: 57.75
+	Hs
		730393 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		UBP15_HUMAN (1-924): 0: 749: 58.17
+	Hs
		798616 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		UBP11_HUMAN (6-937): 0: 717: 44.60
+	Sc
		693618 PRS7_YEAST (84-391): 1.53e-111: 336: 54.87		UBP4_YEAST (698-922): 1.12e-53: 204: 26.61
+	Dm
		186175 PRS8_DROME (8-123): 6.29e-11: 65.5: 7.76		X2JLM6_DROME (583-922): 2.75e-58: 212: 20.23