HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: UBQL4 (Q9NRR5)
Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75)
Gene: UBQLN4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29666234
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031410 - cytoplasmic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 601
+	Hs
		906929 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		UBQL4_HUMAN (1-601): 6.41e-143: 429: 100.00
+	Hs
		907185 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		UBQL1_HUMAN (11-601): 1.16e-127: 389: 59.16
+	Hs
		907182 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Mm
		907218 PRS8_MOUSE (1-406): 1.42e-136: 398: 100.00		UBQL2_MOUSE (11-601): 1.31e-116: 362: 54.04
+	Hs
		906941 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		UBQL2_HUMAN (9-601): 6.99e-118: 365: 51.59
+	Dm
		820528 PRS4_DROME (4-396): 3.02e-138: 403: 45.04		Q9VWD9_DROME (10-594): 3.44e-109: 340: 44.26
+	At
		1352317 PRS4A_ARATH (19-396): 1.25e-158: 455: 47.62		DSK2A_ARATH (19-598): 2.08e-82: 270: 28.76
+	Xl
		804064 PRS8_XENLA (7-406): 3.19e-136: 399: 97.25		BAG6A_XENLA (13-547): 2.1e-69: 245: 18.02
+	At
		1092354 PRS4B_ARATH (19-396): 1.44e-158: 455: 47.62		UBQ3_ARATH (9-88): 1.35e-32: 129: 30.86
+	At
		1092413 PRS4A_ARATH (19-396): 1.25e-158: 455: 47.62		UBQ3_ARATH (9-88): 1.35e-32: 129: 30.86
+	Hs
		872134 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RD23A_HUMAN (13-318): 1.95e-47: 172: 16.37
+	Hs
		872133 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		RD23A_HUMAN (13-318): 1.95e-47: 172: 16.37
+	Rn
		907221 PRS8_RAT (1-406): 1.42e-136: 398: 100.00		RD23B_RAT (13-275): 1.12e-39: 152: 17.40
+	Hs
		872249 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RD23B_HUMAN (13-275): 2e-37: 145: 18.29
+	Rn
		906973 PRS4_RAT (4-396): 7.85e-130: 382: 46.31		RD23B_RAT (13-275): 1.12e-39: 152: 17.40
+	At
		1092308 PRS6B_ARATH (2-403): 2.14e-137: 400: 40.05		UBQ3_ARATH (9-88): 1.35e-32: 129: 30.86
+	Hs
		872248 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		RD23B_HUMAN (13-275): 2e-37: 145: 18.29
+	Hs
		906983 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RL40_HUMAN (13-103): 6.24e-34: 127: 28.26
+	Hs
		906808 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		RL40_HUMAN (13-103): 6.24e-34: 127: 28.26
+	Hs
		906982 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RS27A_HUMAN (13-99): 1.11e-12: 68.1: 29.55