HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27114451
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031410 - cytoplasmic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 589
+	Hs
		906946 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		907182 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Mm
		907218 PRS8_MOUSE (1-406): 1.42e-136: 398: 100.00		UBQL2_MOUSE (1-589): 8.33e-141: 424: 65.47
+	Hs
		906941 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Dm
		820528 PRS4_DROME (4-396): 3.02e-138: 403: 45.04		Q9VWD9_DROME (30-582): 3.32e-135: 407: 47.39
+	Hs
		907171 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Hs
		798776 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	At
		1352317 PRS4A_ARATH (19-396): 1.25e-158: 455: 47.62		DSK2A_ARATH (19-586): 8.36e-108: 336: 32.87
+	Hs
		906929 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Xl
		804064 PRS8_XENLA (7-406): 3.19e-136: 399: 97.25		BAG6A_XENLA (31-536): 8.79e-64: 229: 15.26
+	Hs
		907106 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		DDI1_HUMAN (47-318): 6.39e-53: 187: 15.60
+	Hs
		907059 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Hs
		906885 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		DDI1_HUMAN (47-318): 6.39e-53: 187: 15.60
+	Hs
		906853 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Hs
		798721 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		DDI1_HUMAN (47-318): 6.39e-53: 187: 15.60
+	Hs
		798691 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Hs
		906983 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Hs
		906808 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Hs
		798608 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		BAG6_HUMAN (25-536): 2.14e-33: 138: 14.66
+	Hs
		906982 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68