HitPredict

Interactor 1: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	28514442, 33961781, 17353931, 14743216
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 406 Hs			1 522
+	Hs
		906955 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		798790 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		730394 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		907024 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Mm
		907209 PRS8_MOUSE (1-406): 1.42e-136: 398: 100.00		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Hs
		906899 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Mm
		906963 PRS4_MOUSE (4-396): 7.85e-130: 382: 46.31		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Hs
		907150 PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Mm
		872740 PRS6B_MOUSE (1-399): 8.58e-122: 360: 41.86		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Mm
		1143657 Q8BVQ9_MOUSE (84-392): 1.06e-114: 345: 56.31		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Hs
		913375 PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		798752 PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		730349 PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		906883 PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Mm
		1061801 Q14AQ1_MOUSE (8-101): 2.13e-10: 64: 10.64		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17