HitPredict

Interactor 1: UB2G1 (P62253)
Ubiquitin-conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed]
Gene: UBE2G1

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20804422
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 170 Hs			1 757
+	Hs
		919869 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		SMUF1_HUMAN (1-757): 0: 891: 100.00
+	Hs
		919867 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		908265 UB2G1_HUMAN (1-170): 2.18e-78: 232: 100.00		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		1174523 UB2R2_HUMAN (1-163): 6.15e-72: 218: 54.27		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		1294888 UB2D4_HUMAN (5-165): 1.53e-71: 213: 34.16		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		828008 UB2R1_HUMAN (1-163): 6.6e-70: 213: 51.83		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		919827 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125247 UB2R1_HUMAN (1-163): 6.6e-70: 213: 51.83		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125808 UB2D4_HUMAN (5-165): 1.53e-71: 213: 34.16		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125262 UB2D1_HUMAN (5-165): 3.89e-71: 212: 34.78		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125335 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		808052 UB2D1_HUMAN (5-165): 3.89e-71: 212: 34.78		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		808078 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		908259 UB2G1_HUMAN (1-170): 2.18e-78: 232: 100.00		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Hs
		919765 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Hs
		828010 UB2R1_HUMAN (1-163): 6.6e-70: 213: 51.83		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		919834 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		919860 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		919762 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		HECW1_HUMAN (2-213): 2.55e-19: 95.6: 15.28
+	Hs
		919889 UB2D2_HUMAN (5-165): 1.03e-70: 212: 32.92		HECW2_HUMAN (1-322): 1.89e-15: 82.9: 14.87