HitPredict

Interactor 1: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Interactor 2: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38113892
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UQ_con~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 158
+	Hs
		1377464 UB2D4_HUMAN (7-150): 2.75e-73: 218: 31.08		UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42
+	Zm
		74428 B4FCQ9_MAIZE (7-151): 2.23e-72: 216: 29.53		B4FCQ9_MAIZE (4-157): 6.06e-75: 221: 35.71
+	Hs
		849296 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		919702 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07
+	Zm
		79635 B6SZE0_MAIZE (7-151): 8.29e-72: 215: 29.53		B6SZE0_MAIZE (4-157): 1.96e-74: 220: 35.71
+	Hs
		895960 UB2D4_HUMAN (7-150): 2.75e-73: 218: 31.08		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		895770 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		849299 UB2D1_HUMAN (7-150): 2.2e-72: 216: 32.43		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Zm
		41174 A0A1D6NGW9_MAIZE (7-146): 2.15e-70: 214: 29.17		A0A1D6NGW9_MAIZE (4-153): 5.96e-72: 217: 35.33
+	Hs
		895766 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Sc
		549782 UBC4_YEAST (1-149): 7.24e-71: 212: 32.03		UBC4_YEAST (1-156): 1.22e-72: 216: 35.90
+	Sc
		549783 UBC4_YEAST (1-149): 7.24e-71: 212: 32.03		UBC5_YEAST (1-156): 5.84e-72: 214: 35.26
+	Zm
		8399 A0A1D6ENM7_MAIZE (4-151): 8e-73: 218: 29.61		A0A1D6LKH6_MAIZE (1-154): 6.82e-67: 202: 38.31
+	Hs
		1297356 UB2E2_HUMAN (5-150): 1.61e-65: 201: 27.33		UB2E2_HUMAN (3-156): 7.29e-69: 208: 33.77
+	Hs
		1282318 UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00		UB2E3_HUMAN (3-156): 2.14e-68: 207: 33.77