HitPredict

Interactor 1: UBE2H (P62256)
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)
Gene: UBE2H

Interactor 2: MAEA (Q7L5Y9)
E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10) (Macrophage erythroblast attacher) (P44EMLP)
Gene: MAEA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	29911972, 38113892
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 396
+	Hs
		895826 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		MAEA_HUMAN (1-396): 2.81e-151: 434: 100.00
+	Hs
		1291949 UB2D4_HUMAN (7-150): 2.75e-73: 218: 31.08		RMD5B_HUMAN (20-395): 5.6e-116: 345: 20.00
+	Hs
		919825 UB2D2_HUMAN (7-150): 8.88e-73: 217: 29.73		RMD5B_HUMAN (20-395): 5.6e-116: 345: 20.00
+	Hs
		895879 UB2D3_HUMAN (7-150): 5.39e-71: 213: 29.05		RMD5B_HUMAN (20-395): 5.6e-116: 345: 20.00
+	Hs
		909134 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		RMD5A_HUMAN (21-395): 8.17e-121: 357: 20.41
+	Hs
		1282327 UB2E3_HUMAN (5-150): 1.84e-65: 201: 28.00		RMD5B_HUMAN (20-395): 5.6e-116: 345: 20.00
+	Hs
		851869 UB2E1_HUMAN (5-150): 3.02e-64: 197: 27.33		RMD5B_HUMAN (20-395): 5.6e-116: 345: 20.00
+	Hs
		908953 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		RMD5B_HUMAN (20-395): 5.6e-116: 345: 20.00
+	Sc
		657146 UBC8_YEAST (5-157): 4e-64: 198: 58.44		RMD5_YEAST (27-396): 4.87e-76: 243: 15.48
+	Zm
		35306 A0A1D6LKH6_MAIZE (4-152): 4.18e-65: 199: 30.07		A0A1D6Q353_MAIZE (113-335): 1.41e-46: 167: 13.01
+	Hs
		909215 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		GID8_HUMAN (101-284): 3.5e-47: 162: 20.32
+	Sc
		657140 UBC8_YEAST (5-157): 4e-64: 198: 58.44		VID30_YEAST (122-313): 1.1e-29: 123: 10.78
+	Hs
		908985 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		RANB9_HUMAN (116-215): 3.98e-25: 109: 17.00
+	Hs
		908718 UBE2H_HUMAN (1-183): 8.84e-64: 196: 100.00		RBP10_HUMAN (114-215): 1.14e-23: 104: 15.69
+	Sc
		657137 UBC8_YEAST (5-157): 4e-64: 198: 58.44		FYV10_YEAST (254-394): 6.39e-20: 93.3: 25.56