HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: CDK16 (Q00536)
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
Gene: CDK16

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	35271311, 25852190, 32707033, 36931259
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 496
+	Hs
		909449 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67
+	Hs
		625306 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Hs
		909447 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06
+	Hs
		909472 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK18_HUMAN (1-490): 5.61e-137: 405: 61.84
+	Hs
		300632 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		841132 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69
+	Dm
		955007 1433E_DROME (1-254): 2.95e-146: 411: 82.69		Q7KM03_DROME (4-479): 4.35e-136: 404: 43.81
+	Dm
		955011 1433E_DROME (1-254): 2.95e-146: 411: 82.69		Q94888_DROME (4-479): 1.48e-135: 402: 44.47
+	At
		965298 14332_ARATH (4-255): 1.05e-147: 414: 74.41		MPK7_ARATH (152-490): 6.63e-132: 388: 31.79
+	Sc
		565487 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		PHO85_YEAST (163-451): 5.83e-132: 386: 53.36