HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: FOXO1 (Q12778)
Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)
Gene: FOXO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.671

Property	Details
Experiments	35271311, 36931259, 36964488
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 655
+	Hs
		206820 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		FOXO3_HUMAN (4-655): 4.4e-83: 277: 39.00
+	Hs
		909442 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		FOXO4_HUMAN (3-634): 7.43e-45: 169: 34.65
+	Hs
		909439 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		FOXK1_HUMAN (15-550): 3.5e-43: 168: 15.78
+	Hs
		909499 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		FOXC1_HUMAN (120-282): 1.05e-43: 167: 31.33
+	Sc
		664890 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		FKH2_YEAST (26-635): 6.02e-56: 206: 14.58
+	Dm
		955013 1433E_DROME (1-254): 2.95e-146: 411: 82.69		FOXO_DROME (88-470): 3.72e-39: 154: 34.27