HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: KIBRA (Q8IX03)
Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1)
Gene: WWC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	24366813, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 1113
+	Hs
		909674 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		WWC2_HUMAN (5-1113): 0: 779: 48.44
+	Mm
		93264 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		E9PXB7_MOUSE (2-423): 1.73e-84: 294: 16.77
+	Mm
		808343 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		NEDD4_MOUSE (631-1101): 1.65e-38: 157: 12.04
+	Rn
		910358 1433E_RAT (1-255): 4.87e-154: 430: 100.00		NEDD4_RAT (631-1021): 7.1e-38: 155: 13.81
+	Hs
		909930 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		NED4L_HUMAN (656-807): 2.04e-33: 141: 15.09
+	Mm
		910302 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		NED4L_MOUSE (671-807): 7.62e-32: 136: 13.29
+	Mm
		910341 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		RIMS2_MOUSE (325-788): 4.23e-22: 105: 11.64
+	Hs
		125318 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		WWP2_HUMAN (35-303): 1.01e-10: 68.2: 16.36
+	Hs
		808460 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		YAP1_HUMAN (37-159): 1.07e-10: 67.6: 19.84
+	Hs
		808077 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		NEDD4_HUMAN (26-161): 2.24e-09: 64: 21.32
+	Sc
		712922 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		RSP5_YEAST (673-956): 5.26e-12: 72.5: 11.44
+	Sc
		664848 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		RSP5_YEAST (673-956): 5.26e-12: 72.5: 11.44