HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: HIPK4 (Q8NE63)
Homeodomain-interacting protein kinase 4 (EC 2.7.11.1)
Gene: HIPK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 616
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (4-589): 1.54e-119: 374: 15.37
+	Mm
		910234 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK2_MOUSE (4-610): 9.48e-119: 372: 13.59
+	Hs
		909730 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK2_HUMAN (4-610): 5.48e-118: 370: 13.66
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (4-589): 2.2e-118: 370: 14.70
+	Hs
		625306 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK2_HUMAN (8-281): 8.05e-123: 366: 26.17
+	Hs
		909531 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KCC2G_HUMAN (3-425): 3.45e-118: 364: 17.95
+	Xl
		223345 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q8QGV3_XENLA (4-605): 1.17e-116: 367: 13.60
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (4-605): 7.58e-117: 365: 14.61
+	Hs
		909447 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		CDK3_HUMAN (8-293): 2.82e-120: 360: 25.16
+	Rn
		871214 1433E_RAT (1-255): 4.87e-154: 430: 100.00		AAPK1_RAT (7-540): 3.74e-116: 359: 18.46
+	Hs
		909532 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KCC2D_HUMAN (2-326): 8.49e-117: 358: 20.00
+	Hs
		909507 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AAPK1_HUMAN (7-540): 2.52e-115: 357: 18.13
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (7-425): 2.29e-117: 359: 17.36
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (7-425): 2.29e-117: 359: 17.36
+	Hs
		909877 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYRK2_HUMAN (10-403): 7.89e-109: 341: 30.63
+	At
		965298 14332_ARATH (4-255): 1.05e-147: 414: 74.41		MPK7_ARATH (2-362): 3.57e-113: 344: 23.85
+	Hs
		909539 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYR1A_HUMAN (9-346): 3.79e-54: 199: 38.30
+	Mm
		910255 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		DYR1A_MOUSE (9-346): 4.66e-54: 198: 38.30
+	Hs
		910066 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYRK4_HUMAN (11-347): 8.22e-53: 191: 34.62
+	Hs
		910197 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DYR1B_HUMAN (11-360): 2.49e-52: 191: 37.68