HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: NEK9 (Q8TD19)
Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)
Gene: NEK9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0007346 - regulation of mitotic cell cycle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 979
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (2-481): 1.09e-140: 439: 20.04
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (2-481): 1.57e-137: 432: 20.00
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (2-481): 1.21e-135: 427: 19.59
+	Hs
		909730 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK2_HUMAN (1-446): 1.65e-131: 417: 19.91
+	Xl
		223345 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q8QGV3_XENLA (2-484): 9.86e-133: 420: 19.79
+	Mm
		910234 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK2_MOUSE (1-473): 1.83e-129: 411: 18.57
+	Mm
		910318 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK1_MOUSE (2-476): 3.04e-126: 403: 18.33
+	Hs
		681770 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AKT1_HUMAN (13-377): 4.73e-129: 400: 20.70
+	Hs
		909512 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		STK3_HUMAN (27-485): 6.35e-129: 400: 20.09
+	Hs
		909502 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		STK4_HUMAN (29-485): 3.87e-126: 393: 22.17
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (35-406): 1.02e-126: 394: 22.69
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (35-406): 1.02e-126: 394: 22.69
+	At
		965291 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CDPK1_ARATH (6-410): 7.92e-125: 393: 19.61
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (35-406): 1.02e-126: 394: 22.69
+	At
		802001 14334_ARATH (4-255): 2.51e-145: 408: 73.62		CDPK1_ARATH (6-410): 7.92e-125: 393: 19.61
+	At
		788694 14335_ARATH (2-255): 3.04e-141: 398: 68.75		CDPK1_ARATH (6-410): 7.92e-125: 393: 19.61
+	Hs
		909932 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		NEK1_HUMAN (52-311): 4.47e-61: 229: 42.31
+	Hs
		851417 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		NEK4_HUMAN (52-361): 1.15e-56: 213: 36.78
+	Hs
		910097 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		PLK2_HUMAN (56-303): 6.19e-32: 135: 31.73