HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: SH3R3 (Q8TEJ3)
E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)
Gene: SH3RF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 882
+	Hs
		909744 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SH3R1_HUMAN (46-882): 1.03e-98: 330: 42.17
+	Mm
		910242 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		SRBS2_MOUSE (286-882): 2.2e-22: 105: 12.62
+	Hs
		909656 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SPD2A_HUMAN (59-881): 2.54e-21: 102: 10.28
+	Mm
		292560 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		SPD2A_MOUSE (110-881): 2.78e-20: 99.1: 8.87
+	Hs
		298967 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SRBS2_HUMAN (523-882): 1.7e-18: 93.2: 14.79
+	Hs
		299007 V9HW98_HUMAN (1-255): 4.87e-154: 430: 100.00		SRBS2_HUMAN (523-882): 1.7e-18: 93.2: 14.79
+	Hs
		275184 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		GRAP2_HUMAN (816-882): 9.26e-17: 84.5: 19.40
+	Hs
		909551 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ARHG7_HUMAN (829-882): 7.71e-16: 84.1: 37.04
+	Hs
		909634 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SH319_HUMAN (166-251): 5.64e-14: 78.1: 29.07
+	Hs
		909544 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SPTN1_HUMAN (652-882): 1.46e-12: 74.1: 13.79
+	Hs
		909706 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		DNMBP_HUMAN (666-881): 2.63e-10: 66.6: 10.22
+	Hs
		909979 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SRBS1_HUMAN (122-250): 1.3e-09: 64.4: 20.61