HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: HDAC7 (Q8WUI4)
Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a) (Protein deacetylase HDAC7) (EC 3.5.1.-)
Gene: HDAC7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	17369396, 17979178, 20224040, 23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 952
+	Mm
		910299 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		HDAC7_MOUSE (1-952): 0: 986: 85.42
+	Hs
		880661 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC4_HUMAN (20-939): 0: 958: 48.44
+	Hs
		910144 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC9_HUMAN (20-892): 0: 869: 43.28
+	Mm
		910239 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		Q3UJF1_MOUSE (20-950): 0: 851: 41.88
+	Hs
		910173 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC5_HUMAN (20-950): 0: 850: 41.21
+	Mm
		910352 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		HDAC5_MOUSE (20-950): 0: 842: 41.49
+	Hs
		909530 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC1_HUMAN (510-916): 1.27e-170: 507: 21.91
+	Hs
		177251 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC3_HUMAN (518-951): 2.59e-161: 481: 20.00
+	Sc
		693004 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		RPD3_YEAST (508-948): 2.03e-165: 492: 20.71
+	Sc
		664709 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		RPD3_YEAST (508-948): 2.03e-165: 492: 20.71
+	At
		817061 14310_ARATH (2-254): 2.39e-137: 388: 71.15		HDA5_ARATH (494-948): 4.89e-159: 484: 37.12
+	Hs
		910121 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		HDAC6_HUMAN (443-951): 2.96e-115: 383: 30.33