HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 986
+	Hs
		909491 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		AKP13_HUMAN (37-964): 2.77e-144: 478: 35.95
+	Mm
		910228 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		ARG28_MOUSE (11-876): 1.46e-135: 448: 35.73
+	Hs
		909803 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ARG28_HUMAN (11-875): 8.11e-130: 432: 35.80
+	Hs
		909921 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SPT13_HUMAN (22-648): 3.96e-103: 338: 11.95
+	Hs
		909551 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77
+	Hs
		909501 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14
+	Hs
		910068 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ARHG4_HUMAN (72-648): 7.86e-86: 292: 12.85
+	Hs
		909662 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		ARHGG_HUMAN (111-623): 6.11e-82: 282: 18.06