HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: MARK4 (Q96L34)
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Gene: MARK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35271311, 16306228
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 752
+	Mm
		910308 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK4_MOUSE (1-752): 0: 731: 97.61
+	Hs
		647862 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK3_HUMAN (1-752): 0: 701: 58.56
+	Mm
		910231 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK3_MOUSE (1-752): 0: 700: 58.69
+	Xl
		223344 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q804T2_XENLA (1-752): 0: 692: 59.95
+	Xl
		223345 O57468_XENLA (1-255): 1.7e-152: 426: 96.47		Q8QGV3_XENLA (1-752): 0: 650: 49.75
+	Mm
		910234 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK2_MOUSE (2-752): 0: 641: 49.69
+	Hs
		909730 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK2_HUMAN (2-752): 0: 639: 48.15
+	Hs
		910106 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MARK1_HUMAN (1-752): 0: 632: 51.06
+	Mm
		910318 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		MARK1_MOUSE (1-752): 0: 631: 51.06
+	Dm
		90534 1433E_DROME (1-254): 2.95e-146: 411: 82.69		E1JGN0_DROME (2-752): 0: 611: 45.28
+	Hs
		909567 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		MELK_HUMAN (59-752): 1.3e-176: 522: 26.44
+	Hs
		910071 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SNRK_HUMAN (59-603): 9.4e-160: 483: 32.55
+	Mm
		910272 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		BRSK2_MOUSE (55-504): 8.46e-147: 448: 36.66
+	Hs
		909786 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		BRSK2_HUMAN (55-504): 2.77e-146: 447: 36.66
+	Hs
		883214 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK1_HUMAN (37-662): 2.63e-142: 438: 33.74
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (45-372): 1.2e-138: 419: 37.35
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (45-372): 1.2e-138: 419: 37.35
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (45-372): 1.2e-138: 419: 37.35
+	Hs
		910187 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK3_HUMAN (56-367): 1.81e-109: 363: 59.32
+	Hs
		910013 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK2_HUMAN (56-367): 5.39e-104: 341: 55.17