HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: PI3R4 (Q99570)
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)
Gene: PIK3R4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, 19608861, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 1358
+	Hs
		910013 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK2_HUMAN (10-996): 3.01e-151: 483: 12.43
+	Sc
		630981 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		KCC4_YEAST (7-941): 7.3e-143: 464: 14.06
+	At
		965360 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (1-491): 3.68e-113: 366: 15.32
+	At
		788672 14333_ARATH (1-253): 3.45e-147: 413: 74.12		CIPKC_ARATH (1-491): 3.68e-113: 366: 15.32
+	At
		1280891 14337_ARATH (2-255): 7.73e-147: 412: 71.21		CIPKC_ARATH (1-491): 3.68e-113: 366: 15.32
+	Hs
		909532 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91
+	Hs
		910174 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		KCC2A_HUMAN (24-470): 2.2e-98: 325: 15.35
+	Sc
		419854 BMH2_YEAST (4-242): 1.14e-134: 382: 77.08		SNF1_YEAST (23-501): 2.82e-108: 358: 15.04
+	Sc
		419824 BMH1_YEAST (2-243): 2.43e-134: 381: 75.72		SNF1_YEAST (23-501): 2.82e-108: 358: 15.04
+	At
		965300 14332_ARATH (4-255): 1.05e-147: 414: 74.41		PRL2_ARATH (811-1289): 1.52e-83: 284: 15.46
+	Mm
		910266 1433E_MOUSE (1-255): 4.87e-154: 430: 100.00		NUAK1_MOUSE (2-311): 1.93e-75: 266: 21.56
+	Hs
		229938 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		NUAK1_HUMAN (6-311): 7.6e-74: 262: 21.20
+	Hs
		910009 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		NUAK2_HUMAN (7-311): 1.51e-67: 242: 18.91
+	Hs
		883214 1433E_HUMAN (1-255): 4.87e-154: 430: 100.00		SIK1_HUMAN (26-333): 4.95e-60: 224: 17.98
+	At
		788540 14333_ARATH (1-253): 3.45e-147: 413: 74.12		PRL1_ARATH (761-1189): 1.23e-13: 77.2: 12.47