HitPredict

Interactor 1: RUXF (P62306)
Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF)
Gene: SNRPF

Interactor 2: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex GO:0071007 - U2-type catalytic step 2 spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 86 Hs			1 504
+	Sp
		144083 RUXF_SCHPO (3-74): 9.06e-29: 99: 66.67		PRP19_SCHPO (3-501): 3.8e-95: 298: 27.24
+	Sp
		144146 SMD3_SCHPO (8-76): 1.62e-23: 87.3: 23.19		PRP19_SCHPO (3-501): 3.8e-95: 298: 27.24
+	Hs
		912695 SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22		FBXW7_HUMAN (88-458): 1.1e-73: 248: 18.06
+	Hs
		1288409 LSM4_HUMAN (7-80): 5.94e-33: 112: 32.00		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		911927 RUXF_HUMAN (1-75): 6.7e-33: 110: 100.00		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		197113 LSM4_HUMAN (7-80): 5.94e-33: 112: 32.00		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		196988 RUXF_HUMAN (1-75): 6.7e-33: 110: 100.00		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		1288404 LSM2_HUMAN (9-86): 6.59e-24: 88: 28.40		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		196991 LSM6_HUMAN (3-77): 1.23e-30: 104: 45.33		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		912701 SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22		SNR40_HUMAN (298-504): 7e-58: 197: 21.91
+	Hs
		197110 LSM2_HUMAN (9-86): 6.59e-24: 88: 28.40		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		903646 LSM4_HUMAN (7-80): 5.94e-33: 112: 32.00		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		903090 RUXF_HUMAN (1-75): 6.7e-33: 110: 100.00		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		196993 SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22		PRP4_HUMAN (308-504): 2.63e-48: 176: 18.84
+	Hs
		903627 LSM2_HUMAN (9-86): 6.59e-24: 88: 28.40		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Hs
		903093 SMD3_HUMAN (5-76): 4.51e-21: 81.9: 22.22		WDR5_HUMAN (93-333): 2.8e-41: 152: 15.48
+	Sc
		692309 SMD3_YEAST (1-76): 1.44e-26: 95: 25.00		PRP19_YEAST (3-138): 1.03e-22: 103: 38.19
+	Sc
		589082 SMD3_YEAST (1-76): 1.44e-26: 95: 25.00		PRP4_YEAST (186-503): 1.58e-22: 102: 24.92
+	Sc
		692335 RUXF_YEAST (4-77): 6.37e-26: 93: 56.00		PRP19_YEAST (3-138): 1.03e-22: 103: 38.19
+	Sc
		589090 RUXF_YEAST (4-77): 6.37e-26: 93: 56.00		PRP4_YEAST (186-503): 1.58e-22: 102: 24.92