HitPredict

Interactor 1: LSM6 (P62312)
U6 snRNA-associated Sm-like protein LSm6
Gene: LSM6

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 80 Hs			1 551
+	Mm
		1156802 LSM4_MOUSE (8-80): 6.8e-34: 114: 27.03		CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62
+	Hs
		1084679 LSM4_HUMAN (8-80): 5.81e-33: 112: 27.03		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		911853 RUXF_HUMAN (5-74): 6.03e-31: 105: 48.57		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084671 LSM2_HUMAN (10-80): 3.6e-20: 78.4: 27.03		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		912649 SMD3_HUMAN (8-77): 5.73e-19: 76.1: 21.43		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		911897 RUXF_HUMAN (5-74): 6.03e-31: 105: 48.57		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		302278 RUXF_HUMAN (5-74): 6.03e-31: 105: 48.57		SC31A_HUMAN (127-488): 4.72e-28: 121: 14.25
+	Hs
		911949 RUXF_HUMAN (5-74): 6.03e-31: 105: 48.57		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Sc
		376892 RUXF_YEAST (2-75): 1.15e-26: 94.6: 40.00		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Sc
		376759 LSM2_YEAST (10-80): 8.12e-19: 74.9: 25.68		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Sc
		376804 LSM4_YEAST (8-80): 1.63e-11: 58.4: 21.43		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Sc
		376893 LSM3_YEAST (6-78): 2.79e-09: 50.3: 28.75		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96