HitPredict

Interactor 1: SMD3 (P62318)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SNRPD3

Interactor 2: SART3 (Q15020)
Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)
Gene: SART3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~Lsm_interact
Common GO terms	GO:0000387 - spliceosomal snRNP assembly GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 963
+	Hs
		1063317 LSM4_HUMAN (5-84): 8.75e-35: 118: 30.86		SART3_HUMAN (1-963): 0: 638: 100.00
+	Hs
		1063313 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		SART3_HUMAN (1-963): 0: 638: 100.00
+	Hs
		911838 RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66		SART3_HUMAN (1-963): 0: 638: 100.00
+	Ce
		1088762 SMD3_CAEEL (2-119): 1.43e-35: 120: 59.84		SART3_CAEEL (73-962): 3.23e-124: 399: 24.26
+	Ce
		1013433 SMD1_CAEEL (7-91): 8.95e-30: 105: 23.53		SART3_CAEEL (73-962): 3.23e-124: 399: 24.26
+	Hs
		1318167 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		CRNL1_HUMAN (36-683): 9.67e-110: 360: 14.35
+	Hs
		911958 RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66		CRNL1_HUMAN (36-683): 9.67e-110: 360: 14.35
+	Hs
		300104 SMD3_HUMAN (1-126): 1.77e-42: 137: 100.00		PRP6_HUMAN (20-640): 4.55e-83: 290: 13.10
+	Hs
		300299 LSM4_HUMAN (5-84): 8.75e-35: 118: 30.86		PRP6_HUMAN (20-640): 4.55e-83: 290: 13.10
+	Hs
		300294 LSM2_HUMAN (8-91): 1.44e-30: 106: 22.09		PRP6_HUMAN (20-640): 4.55e-83: 290: 13.10
+	Hs
		300099 RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66		PRP6_HUMAN (20-640): 4.55e-83: 290: 13.10
+	Sc
		795434 SMD3_YEAST (4-102): 3.26e-30: 105: 43.43		CLF1_YEAST (48-658): 1.77e-74: 260: 13.68
+	Hs
		641701 SMD1_HUMAN (7-94): 9.52e-33: 112: 27.27		U2AF2_HUMAN (620-894): 8.59e-67: 233: 23.36
+	Sc
		763234 SMD3_YEAST (4-102): 3.26e-30: 105: 43.43		PRP39_YEAST (130-596): 1.57e-67: 239: 13.25
+	Zm
		8170 B6UER1_MAIZE (8-94): 3.25e-31: 108: 24.72		A0A1D6ELI3_MAIZE (697-948): 2.22e-55: 207: 25.28
+	Hs
		912738 SMD3_HUMAN (1-126): 1.77e-42: 137: 100.00		SYF1_HUMAN (34-365): 2.09e-14: 79.7: 12.39
+	Dm
		1369701 Q9VKW8_DROME (5-120): 5.11e-35: 119: 24.06		RNP4F_DROME (791-895): 5.63e-16: 85.1: 40.00
+	Sp
		1015547 SMD3_SCHPO (3-99): 3.75e-32: 110: 59.79		PRP1_SCHPO (35-363): 5.2e-15: 82: 11.64
+	Sp
		193907 SMD1_SCHPO (7-94): 1.13e-31: 110: 23.86		PRP1_SCHPO (35-363): 5.2e-15: 82: 11.64
+	Hs
		911970 RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66		SYF1_HUMAN (34-365): 2.09e-14: 79.7: 12.39