HitPredict

Interactor 1: ARF6 (P62330)
ADP-ribosylation factor 6 (EC 3.6.5.2)
Gene: ARF6

Interactor 2: AGAP1 (Q9UPQ3)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)
Gene: AGAP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	22453919, 34079125, 35844135
Identification Methods	enzymatic study, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~Arf, Arf~ArfGap
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 857
+	Hs
		950579 ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39		AGAP1_HUMAN (1-857): 0: 850: 100.00
+	Hs
		913052 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		AGAP3_HUMAN (4-827): 0: 768: 72.46
+	Hs
		950547 ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39		AGAP2_HUMAN (52-827): 0: 597: 52.94
+	Hs
		912911 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		ACAP2_HUMAN (308-854): 7.28e-132: 414: 16.55
+	Mm
		1186345 RAB1B_MOUSE (10-174): 3.3e-66: 202: 19.41		ASAP2_MOUSE (367-855): 3.55e-96: 324: 19.77
+	Hs
		950577 ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39		ASAP1_HUMAN (367-855): 1.34e-86: 300: 20.87
+	Hs
		913181 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		ASAP1_HUMAN (367-855): 1.34e-86: 300: 20.87
+	Hs
		913022 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		ARAP2_HUMAN (556-846): 2.29e-75: 271: 27.70
+	Hs
		950582 ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39		GIT1_HUMAN (616-848): 2.84e-73: 257: 31.58
+	Zm
		73944 B4FAE1_MAIZE (10-175): 6.71e-69: 209: 20.47		B4FAE1_MAIZE (68-273): 7.21e-79: 255: 21.13
+	Hs
		912909 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		ACAP1_HUMAN (306-788): 5.15e-74: 258: 15.47
+	Hs
		913202 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		GIT1_HUMAN (616-848): 2.84e-73: 257: 31.58
+	Hs
		918846 RAB1A_HUMAN (1-174): 6.74e-67: 204: 18.99		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		918944 RAB1B_HUMAN (10-174): 1.3e-66: 203: 19.41		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Mm
		919000 RAB1B_MOUSE (10-174): 3.3e-66: 202: 19.41		RAB1A_MOUSE (72-257): 3.27e-72: 237: 24.35
+	Hs
		912837 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		RAB1A_HUMAN (72-257): 3.27e-72: 237: 24.35
+	Hs
		897875 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		RAP1B_HUMAN (69-229): 7.97e-70: 230: 22.75