HitPredict

Interactor 1: ARF6 (P62330)
ADP-ribosylation factor 6 (EC 3.6.5.2)
Gene: ARF6

Interactor 2: JIP3 (Q9UPT6)
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Gene: MAPK8IP3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19211056
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arf~JIP_LZII
Common GO terms	GO:0016192 - vesicle-mediated transport
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 1336
+	Mm
		913233 ARF6_MOUSE (1-175): 2.17e-65: 199: 100.00		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Hs
		229657 ARF1_HUMAN (2-175): 4.43e-69: 209: 68.39		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Mm
		913228 ARF6_MOUSE (1-175): 2.17e-65: 199: 100.00		JIP4_MOUSE (6-1336): 0: 681: 54.61
+	Hs
		229655 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		912888 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		ROCK1_HUMAN (2-581): 2.57e-21: 103: 9.37
+	Hs
		912950 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		MRCKA_HUMAN (2-407): 2.77e-19: 96.9: 12.93
+	Hs
		148636 RAB1A_HUMAN (1-174): 6.74e-67: 204: 18.99		CTRO_HUMAN (1-425): 1.46e-17: 91.4: 9.17
+	Hs
		149274 RAB1B_HUMAN (10-174): 1.3e-66: 203: 19.41		CTRO_HUMAN (1-425): 1.46e-17: 91.4: 9.17
+	Hs
		148603 ARF3_HUMAN (2-175): 4.91e-65: 198: 69.54		CTRO_HUMAN (1-425): 1.46e-17: 91.4: 9.17
+	Hs
		254465 ARF6_HUMAN (1-175): 2.17e-65: 199: 100.00		ROCK2_HUMAN (2-348): 1.31e-13: 78.3: 7.20