HitPredict

Interactor 1: PRS10 (P62333)
26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)
Gene: PSMC6

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 389 Hs			1 1083
+	Hs
		907040 PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		798672 PRS6B_HUMAN (3-383): 3.42e-121: 359: 40.68		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		730268 PRS7_HUMAN (20-377): 3.86e-104: 315: 44.65		UBE3C_HUMAN (1-1083): 0: 1136: 100.00
+	Hs
		913250 PRS10_HUMAN (1-389): 7.27e-137: 397: 100.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		906816 PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		906999 PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		798641 PRS6B_HUMAN (3-383): 3.42e-121: 359: 40.68		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Hs
		907164 PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		798765 PRS6B_HUMAN (3-383): 3.42e-121: 359: 40.68		SMUF1_HUMAN (562-1080): 3.14e-177: 539: 22.78
+	Hs
		730242 PRS7_HUMAN (20-377): 3.86e-104: 315: 44.65		UBE3A_HUMAN (384-1082): 0: 557: 21.73
+	Sc
		859305 PRS8_YEAST (10-387): 8.63e-117: 347: 43.92		HUL5_YEAST (662-1083): 8.08e-75: 268: 39.07
+	Hs
		913303 PRS10_HUMAN (1-389): 7.27e-137: 397: 100.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		906870 PRS4_HUMAN (14-380): 2.44e-135: 395: 41.42		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		907081 PRS8_HUMAN (5-387): 7.73e-122: 360: 47.00		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Hs
		798705 PRS6B_HUMAN (3-383): 3.42e-121: 359: 40.68		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Sc
		968067 PRS8_YEAST (10-387): 8.63e-117: 347: 43.92		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12
+	Hs
		730302 PRS7_HUMAN (20-377): 3.86e-104: 315: 44.65		HUWE1_HUMAN (683-1083): 1.53e-47: 188: 32.60
+	Sc
		703952 PRS7_YEAST (68-386): 2.09e-103: 315: 48.75		TOM1_YEAST (683-1083): 1.4e-46: 185: 32.12