HitPredict

Interactor 1: ERF1 (P62495)
Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)
Gene: ETF1

Interactor 2: ERF3B (Q8IYD1)
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog)
Gene: GSPT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.930

The method score is based on:

Property Details
Experiments 28514442, 33961781, 29395067, 9712840, 18447585
Identification Methods affinity chromatography technology, proximity labelling technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains GTP_EFTU~eRF1_1, GTP_EFTU_D2~eRF1_1, GTP_EFTU~eRF1_2, GTP_EFTU_D2~eRF1_2, GTP_EFTU_D3~eRF1_2, GTP_EFTU_D3~eRF1_3
Common GO terms GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003723 - RNA binding
GO:0003747 - translation release factor activity
GO:0005829 - cytosol
GO:0006415 - translational termination
and 1 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 437
Hs

1 628
+ Hs
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+ Sc
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+ Sp
+ Mm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024