HitPredict

Interactor 1: E7EQY4 (E7EQY4)
Metastasis associated 1 family member 3
Gene: MTA3

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005654 - nucleoplasm GO:0016581 - NuRD complex GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 514 Hs			1 482
+	Hs
		1038676 MTA3_HUMAN (1-511): 0: 668: 99.02		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1270415 MTA3_HUMAN (1-511): 0: 668: 99.02		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		140302 MTA1_MOUSE (1-512): 0: 601: 72.64		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Mm
		140317 MTA2_MOUSE (1-512): 0: 600: 69.32		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Hs
		1031849 MTA1_HUMAN (1-512): 0: 602: 73.02		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1031919 MTA1_HUMAN (1-512): 0: 602: 73.02		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		296017 MTA2_HUMAN (1-512): 0: 597: 69.32		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Mm
		936419 MTA1_MOUSE (1-512): 0: 601: 72.64		HDAC2_MOUSE (1-478): 0: 664: 85.71
+	Mm
		936428 MTA2_MOUSE (1-512): 0: 600: 69.32		HDAC2_MOUSE (1-478): 0: 664: 85.71
+	Hs
		296092 MTA2_HUMAN (1-512): 0: 597: 69.32		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Dm
		81423 B7Z0T5_DROME (10-513): 1.07e-180: 531: 49.00		HDAC1_DROME (6-477): 0: 658: 77.33
+	Mm
		140291 RERE_MOUSE (5-514): 1.64e-129: 413: 23.17		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Hs
		1038770 RERE_HUMAN (5-514): 1.07e-126: 405: 23.00		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1270490 RERE_HUMAN (5-514): 1.07e-126: 405: 23.00		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		1038521 RCOR2_HUMAN (137-514): 1.25e-77: 254: 18.78		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Mm
		936416 RCOR2_MOUSE (137-514): 1.55e-78: 257: 18.78		HDAC2_MOUSE (1-478): 0: 664: 85.71
+	Hs
		1223936 RCOR2_HUMAN (137-514): 1.25e-77: 254: 18.78		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		1038636 TREF1_HUMAN (121-468): 1.92e-69: 243: 17.32		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1038768 RCOR3_HUMAN (150-514): 1.22e-69: 232: 15.55		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		177395 RCOR3_HUMAN (150-514): 1.22e-69: 232: 15.55		HDAC3_HUMAN (9-434): 0: 574: 57.94