HitPredict

Interactor 1: ERR3 (P62508)
Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
Gene: ESRRG

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	15604093, 11864604
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 458 Hs			1 1441
+	Hs
		587177 RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		659718 RXRB_HUMAN (77-456): 3.9e-122: 367: 31.23		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		500364 RARB_HUMAN (34-455): 1.84e-121: 363: 28.37		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		914652 ERR3_HUMAN (1-458): 1.22e-166: 478: 100.00		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Mm
		914681 ERR3_MOUSE (1-458): 1.22e-166: 478: 100.00		EPAS1_MOUSE (15-890): 5.04e-96: 332: 13.94
+	Mm
		864788 ERR3_MOUSE (1-458): 1.22e-166: 478: 100.00		ARNT_MOUSE (4-656): 1.65e-93: 322: 16.20
+	Hs
		320210 ERR2_HUMAN (24-458): 6.11e-146: 425: 77.70		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Mm
		956581 ERR2_MOUSE (24-458): 5.05e-143: 417: 74.94		EPAS1_MOUSE (15-890): 5.04e-96: 332: 13.94
+	Mm
		864795 ERR2_MOUSE (24-458): 5.05e-143: 417: 74.94		ARNT_MOUSE (4-656): 1.65e-93: 322: 16.20
+	Hs
		126103 RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85		BMAL1_HUMAN (1-539): 2.88e-105: 350: 16.16
+	Hs
		320237 ERR2_HUMAN (24-458): 6.11e-146: 425: 77.70		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Mm
		985518 ERR2_MOUSE (24-458): 5.05e-143: 417: 74.94		Q05BA5_MOUSE (1-1411): 1.11e-76: 282: 23.77
+	Mm
		60484 ERR2_MOUSE (24-458): 5.05e-143: 417: 74.94		A5D6Q2_MOUSE (48-1411): 3.96e-70: 261: 22.54
+	Hs
		587212 RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		181498 RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85		CLOCK_HUMAN (5-833): 1.42e-75: 271: 14.15
+	Hs
		490089 COT1_HUMAN (48-454): 7.1e-121: 360: 27.14		AHR_HUMAN (2-833): 8.86e-80: 284: 13.86
+	Hs
		500381 RARB_HUMAN (34-455): 1.84e-121: 363: 28.37		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		320207 ERR2_HUMAN (24-458): 6.11e-146: 425: 77.70		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587173 RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587195 RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85		NPAS2_HUMAN (29-210): 2.08e-09: 64.3: 29.73